Recently, EBioMedicine, a comprehensive sub journal of The Lancet, published a research result on the exploration of the etiology and scoring system of breast cancer. The research was jointly completed by the computational medicine team of Phil Rivers, Guangdong Provincial People's Hospital, Turing Darwin Laboratory, and other research institutions.
Based on the new technology system of computational medicine, the research team took female breast cancer as the specific research object and carried out the world's first clinical trial of embryoline genome etiology. The project team has developed a system called " Damage Assessment of Genomic Mutations" (DAGM), which has greatly improved the research level of breast cancer etiology in China. In the future, APSPs (Activity Profiles of Signalling Pathways) scoring method will be used to guide the early prevention and early diagnosis of breast cancer.
Publication: DAGM: A novel modelling framework to assess the risk of HER2-negative breast cancer based on germline rare coding mutations
Source: China Science Daily